Catherine Sale was born in Belgium. From 1991 to 1994 she attended classes at the Royal Conservatory of Liège, where her teachers were Max Parfondry and Jacques Delcuvellery. Catherine currently lives in Brussels. Sale made her screen debut in 2004. She performed one of the roles in the drama Private Madness, and also starred in the crime drama thriller The Guillotine Knife. In 2006, Catherine acted as one of the screenwriters of the comedy "What Makes You Happy".